Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients

Not Applicable

Completed

• Conditions: Mucociliary Clearance Defect; Physical Disability

• Registration Number: NCT02604082
• Lead Sponsor: Hospital de Clinicas de Porto Alegre

Brief Summary

Randomized clinical trial, conducted in the Intensive Care Unit of the Hospital de Clinicas de Porto Alegre from october 2011 until november 2015 .

Detailed Description

Objective: To compare the effectiveness of techniques: vibrocompression (G1), hyperinflation with mechanical ventilation (G2) vibrocompression + hyperinflation with mechanical ventilation (G3) in the amount of aspirated secretions, mechanical ventilator time, incidence of ventilator-associated pneumonia , reintubation tracheal and mortality in mechanical ventilator. Primary outcome: weight in grams of the aspirated secretions. Secondary outcome: hemodynamic and pulmonary parameters: heart rate, respiratory rate, mean arterial pressure, peripheral arterial oxygen saturation; peak inspiratory pressure, tidal volume; dynamic compliance ; mechanical ventilator time; reintubation tracheal; Incidence of ventilator-associated pneumonia and mortality in mechanical ventilator.

Study Timeline

• Study Start: 2011-09
• Primary Completion: 2015-08
• Status Verified: 2015-11
• Study Completion: 2015-11
• Study First Submitted: 2015-11-06
• Study First Submitted QC: 2015-11-11
• Last Update Submitted: 2015-11-11
• Study First Posted: 2015-11-13
• Last Update Posted: 2015-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 93

Inclusion Criteria

• In mechanical ventilation for a period of 24-72 h
• End-expiratory pressure (PEEP) lower 10 cm of water.
• Lower noradrenaline doses of 0.5mg / kg / minute for an average greater than or equal blood outstrips 60 mmHg.

Exclusion Criteria

• Pneumothorax and hemothorax undrained
• Subcutaneous emphysema
• Osteoporosis
• Acute respiratory distress syndrome - (ARDS)
• Fractures of ribs
• Obese ( BMI greater than 35)
• Mechanical ventilator with higher peak pressures 40 cm of water.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Weight in grams of the pulmonary secretions	up to 24 weeks.

Secondary Outcome Measures

Name	Time	Method
Time mechanical ventilator (MV) in days	Through study completion, an average of 3 years.
Reintubation tracheal in percentage in the last 24 hours	Through study completion, an average of 3 years.
Incidence of ventilator-associated pneumonia in percentage	Through study completion, an average of 3 years.
Mortality in the MV in percentage	Through study completion, an average of 3 years.
Heart Rate	up to 24 weeks.
Respiratory frequency	up to 24 weeks
Peripheral oxygen saturation in percentage	up to 24 weeks
Tidal volume in milliliters	up to 24 weeks
Peak inspiratory pressure in centimeters of water	up to 24 weeks