NCT01165931
Withdrawn
Phase 2
A Study to Compare the Acute Coronary Vasodilating Effects of the sGC Stimulator Riociguat (BAY 63-2521) With the Nitric Oxide Donor Nitroglycerin in Patients With Coronary Artery Disease
Overview
- Phase
- Phase 2
- Intervention
- Riociguat (BAY63-2521)
- Conditions
- Coronary Artery Disease
- Sponsor
- Bayer
- Primary Endpoint
- The ratio of the coronary blood flow after Riociguat to the corresponding flow observed after adenosine, compared to that after nitroglycerin administration
- Status
- Withdrawn
- Last Updated
- 12 years ago
Overview
Brief Summary
The aim of the study is to assess the effects of intracoronary Riociguat on coronary blood flow in subjects with coronary artery disease and to compare this effect with the intracoronary nitroglycerin, a coronary vasodilator widly used to treat patients with coronary artery disease.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Male and female patients with coronary artery disease
Exclusion Criteria
- •Patents with coronary artery disease with \>/= 70% luminal stenosis by coronary angiography in one of the 3 major epicardial coronary arteries (left anterior descending artery \[LAD\], left circumflex coronary artery \[LCX\] or right coronary artery \[RCA\]) undergoing cardiac catheterization
Arms & Interventions
Arm 1
Intervention: Riociguat (BAY63-2521)
Outcomes
Primary Outcomes
The ratio of the coronary blood flow after Riociguat to the corresponding flow observed after adenosine, compared to that after nitroglycerin administration
Time Frame: Within 5 min after completion of the intracoronary Riociguat infusion
Secondary Outcomes
- Adverse event collection(Until 30 days after study drug treatment)
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