Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients

Completed

• Conditions: Heparin-induced Thrombocytopenia; Liver Transplantation

• Registration Number: NCT01654848
• Lead Sponsor: CHIR-Net

Brief Summary

In a prospective observational study the incidence of Heparin-induced Thrombocytopenia (HIT) Type 2 after orthotopic liver transplantation, associated factors, and hemostaseological findings in thrombocytes and anti-body patterns is going to be investigated.

Detailed Description

The investigators examined the frequency of anti-PF4/heparin antibodies (IgG/M/A; EIA) and their functional activity (HIPA) in 38 whole organ deceased donor liver transplant recipients. Additionally, demographic, clinical, donor- and recipient-specific parameters and laboratory findings (ALAT, ASAT, cholinesterase) were investigated.

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Study First Submitted: 2012-03-30
• Status Verified: 2012-07
• Study First Submitted QC: 2012-07-31
• Last Update Submitted: 2012-07-31
• Study First Posted: 2012-08-01
• Last Update Posted: 2012-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

• all consecutive liver transplant recipients between 01/2010 and 08/2011 who
• were transplanted at our center after allocation of a liver graft via Eurotransplant

Exclusion Criteria

• patient's refusal to participate in prospective observation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Klinikum rechts der Isar der TU München; 🇩🇪 Munich, Germany