COMPARATIVE EFFECTIVENESS OF CLONIDINE WITH LIGNOCAINEVERSUS ADRENALINE WITH LIGNOCAINE IN MAXILLARY INFILTRATIONANESTHESIA FOR DENTAL EXTRACTION.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Onset of anesthesia Intensity of anesthesia
Study Overview
Brief Summary
The aim of the present clinical study is to evaluate whether an admixture of clonidine plus 2% lignocaine is an effective alternative to the epinephrine plus 2% lignocaine mixture in terms of Onset of anesthesia, Intensity of anesthesia, hemodynamic response, in patients undergoing bilateral removal of maxillary posterior teeth using maxillary infiltration anesthesia. Study Design: Split mouth double blind study. • Study setting: This study will be conducted in the Department of Oral & Maxillofacial Surgery. • Study Population: 30 Healthy patients aged between 18-60 years requiring removal of bilateral maxillary posterior teeth reporting to department of oral & maxillofacial surgery will be included in the study. • Sampling Technique: Convenience sampling. • Selected patient will be divided into two groups and Extractions will be done in two different appointments . The parameters to be evaluated for the study include: • Age & gender distribution: • Onset of anesthesia • Intensity of anesthesia • Hemodynamic parameters among the both groups: An observer, will be monitored all the patient for o Heart Rate (HR), o Systolic Blood Pressure (SBP) o Diastolic Blood Pressure (DBP). o Mean Arterial Pressure (MAP). • Initial measurements will be obtained prior to anesthesia. • Additional recordings will be made during • Administration of local anesthesia, • During the procedure, • 5 min after administration of anesthesia, • 10 min following completion of the procedure.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •This study will included patients between 18-60yr,
- •Teeth diagnosed with dental caries, teeth which could not be restored and patients who refused conservative management will be included in the study.
- •Patients requiring bilateral orthodontic extraction.
- •Patients willing to participate in the study.
Exclusion Criteria
- •Patients with complains of morbidities such as hypertension, diabetes mellitus, asthma, bleeding disorders.
- •Patient who have known allergies to any drug under study,
- •Pregnant women, nursing mothers and apprehensive patients will be excluded from the study.
- •Patients with impacted teeth will be excluded from the study.
- •Patients with the oro-facial space infection will be excluded from the study.
Outcomes
Primary Outcomes
Onset of anesthesia Intensity of anesthesia
Time Frame: 1.The onset of anesthesia will be investigated by probing with Moons probe every 30 sec. after withdrawal of needle until the probing does not induce pain sensation. | 2.Hemodynamic parameters will be continuously monitored in all patients to record heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure will be taken during administration of local anesthesia, 5 min after administration of anesthesia, during surgery and 10 min following completion of surgery.
Hemodynamic parameters among the both groups: An observer, will be monitored all the patient for
Time Frame: 1.The onset of anesthesia will be investigated by probing with Moons probe every 30 sec. after withdrawal of needle until the probing does not induce pain sensation. | 2.Hemodynamic parameters will be continuously monitored in all patients to record heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure will be taken during administration of local anesthesia, 5 min after administration of anesthesia, during surgery and 10 min following completion of surgery.
Systolic Blood Pressure (SBP)
Time Frame: 1.The onset of anesthesia will be investigated by probing with Moons probe every 30 sec. after withdrawal of needle until the probing does not induce pain sensation. | 2.Hemodynamic parameters will be continuously monitored in all patients to record heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure will be taken during administration of local anesthesia, 5 min after administration of anesthesia, during surgery and 10 min following completion of surgery.
Heart Rate (HR),
Time Frame: 1.The onset of anesthesia will be investigated by probing with Moons probe every 30 sec. after withdrawal of needle until the probing does not induce pain sensation. | 2.Hemodynamic parameters will be continuously monitored in all patients to record heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure will be taken during administration of local anesthesia, 5 min after administration of anesthesia, during surgery and 10 min following completion of surgery.
Diastolic Blood Pressure (DBP).
Time Frame: 1.The onset of anesthesia will be investigated by probing with Moons probe every 30 sec. after withdrawal of needle until the probing does not induce pain sensation. | 2.Hemodynamic parameters will be continuously monitored in all patients to record heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure will be taken during administration of local anesthesia, 5 min after administration of anesthesia, during surgery and 10 min following completion of surgery.
Mean Arterial Pressure (MAP).
Time Frame: 1.The onset of anesthesia will be investigated by probing with Moons probe every 30 sec. after withdrawal of needle until the probing does not induce pain sensation. | 2.Hemodynamic parameters will be continuously monitored in all patients to record heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure will be taken during administration of local anesthesia, 5 min after administration of anesthesia, during surgery and 10 min following completion of surgery.
Secondary Outcomes
- Age & gender distribution:(Onset of anesthesia)