The effect of clonidine as an adjunct to lidocaine on postoperative pain control following root canal treatment

Not Applicable

Completed

• Conditions: Postoperative pain after root canal treatment; Oral Health

• Registration Number: ISRCTN70419178
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34475675/ (added 19/01/2023)

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-01-15
• Study Start: 2016-12-29
• Last Update Posted: 30 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Adult patients (18 years of age or older)
2. In good medical condition (American Society of Anesthesiologists classification 1)
3. Diagnosed with symptomatic irreversible pulpitis and normal/symptomatic apical periodontitis at the mandibular first or second molars

Exclusion Criteria

1. Patients with active signs of oral infections or inflammation
2. History of addiction or use of ß blockers
3. Patients taking any medications that could affect anesthetic assessment (analgesics or opioids at least one week before treatments)
4. Patients with allergies or contraindications to the use of clonidine, epinephrine or ibuprofen
5. Female patients who were pregnant or breastfeeding
6. Patients with no response to cold testing
7. Perirapical pathosis (other than a widened periodontal ligament)
8. No vital coronal pulp tissue upon access cavity preparation (partial necrosis)

Study & Design

• Study Type: Interventional
• Study Design: Not specified