Comparative evaluation of the effect of Clonidine and Atenolol premedication on hemodynamic effects and Propofol dose requirement in patients undergoing ERCP under monitored anesthesia care: a double blind, randomized, placebo controlled study.
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Patients undergoing ERCP under monitored anaesthesia care at SGPGI, Lucknow
- Registration Number
- CTRI/2012/05/002643
- Lead Sponsor
- SGPGI
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 114
Inclusion Criteria
> 18yrs,
Undergoing elective ERCP (diagnostic or therapeutic) under monitored anaesthesia care
Exclusion Criteria
Consent not given
Patients already on Atenolol or Clonidine or on Cardiac Drugs.
Heart rate less 60 per min or Blood Pressure less than 100mgHG systolic.
Pregnant patients.
Emergency procedure.
ASA more than or equal to 4 patients
Patients requiring airway intervention or general anaesthesia.
Expected duration less than 30min or more than 2hours.
Patients with history of drug abuse or allergy to the drugs to be used.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effectiveness of Atenolol and Clonidine premedication in preventing hemodynamic stress and myocardial injury in patients undergoing ERCP under sedation.Timepoint: During procedure and 24 hours after procedure.
- Secondary Outcome Measures
Name Time Method 1.To study the occurrence of adverse effects during ERCP. <br/ ><br>2.To study the hemodynamic response to Buscopan administration. <br/ ><br>3.To study the dose requirement of Propofol during the procedure and the effect of Atenolol and Clonidine premedication on it. <br/ ><br>4.To assess the patient and operator satisfaction with procedures under sedation in our institution. <br/ ><br>5.To evaluate the time of awakening and discharge to ward. <br/ ><br>Timepoint: during procedure and 24 hours after the procedure