eutrophil viability in surgical patients and its relationship with neutrophil functionality

Recruiting

• Conditions: death of white blood cells; neutrophil cell death; 10027665

• Registration Number: NL-OMON49355
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 33

Inclusion Criteria

leukocyte viability factor * 0.95

Exclusion Criteria

Immunosuppressive drugs (e.g. chemotoxic and cytostatic drugs) or positive HIV-status or use of clozapine medication

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint is neutrophil cell death, determined by double staining of<br /><br>Annexin V and PI. This will be compared to the decreased viability factor of<br /><br>the initial routine blood sample to validate the viability factor. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints are neutrophil phagocytosis and responsiveness to fMLP.</p><br>