eonatal thymectomy; consequences for homeostasis and regulation of the immune system?

Recruiting

• Conditions: congenital heartdisease; transposition of the great arteries; 10010394; 10003816; 10007593

• Registration Number: NL-OMON29974
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

Arterial switch operation in the Wilhelmina Kinderziekenhuis between 1977 and 2003

Exclusion Criteria

moved abroad

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Number of FOXP3+ cells compared to healthy controls<br /><br>2) Ratio naïve T cells : memory T cells<br /><br>3) Proliferate rate of naïve and memory T cell pool</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Incidence of autoimmune diseases, malignancies, infectiousdiseases</p><br>