Immune system changes after thymectomy (removal of the thymus gland) and childhood cardiac (heart) transplant

Not Applicable

• Conditions: Response to Epstein Barr virus (EBV) infection in children undergoing heart transplant; Infections and Infestations

• Registration Number: ISRCTN10096625
• Lead Sponsor: ewcastle upon Tyne Hospitals NHS Foundation Trust

Brief Summary

2023 Protocol article in https://doi.org/10.1136/bmjopen-2023-079582 (added 23/10/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-10-17
• Last Update Posted: 8 January 2024
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Resident in the UK.
2. Aged 0 – 18 years.
3. Actively listed on the NHS Blood and Transplant (NHSBT) waiting list for a primary organ transplant OR awaiting transplant with a living related donor kidney OR recently transplanted with pre-transplant blood samples available.
4. Written informed consent.

Exclusion Criteria

1. Has a pre-existing diagnosis of an inherited or acquired immunodeficiency.
2. Has an underlying thymic disorder.
3. Has previously received a bone marrow or organ transplant.
4. Has had a previous cancer diagnosis.
5. Withheld consent.
6. Weight under 2.5kg

Study & Design

• Study Type: Observational
• Study Design: Not specified