Precision Analytic Research Methods in OCD

Not Applicable

Not yet recruiting

• Conditions: Obsessive Compulsive Disorder

• Registration Number: NCT07011901
• Lead Sponsor: Icahn School of Medicine at Mount Sinai

Brief Summary

Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-06
• Study First Submitted: 2025-06-02
• Study First Submitted QC: 2025-06-02
• Last Update Submitted: 2025-06-02
• Study First Posted: 2025-06-10
• Last Update Posted: 2025-06-10
• Study Start: 2025-07-01
• Primary Completion: 2030-03-31
• Study Completion: 2030-03-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Participants must be:

• between the ages 18-55 years old
• English-speaking
• right-handed
• able to provide consent

Exclusion Criteria

Individuals diagnosed with OCD will be excluded if:

• they meet diagnostic criteria for certain other psychiatric disorders
• are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe
• if it is unsafe for them to participate in research

Healthy control participants will be excluded if:

• they have a current psychiatric disorder
• a lifetime history of certain psychiatric disorders
• are taking psychiatric medication or have in the past
• have a parent or sibling who has been diagnosed with OCD
• if it is unsafe for them to participate in research

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Yale Brown Obsessive Compulsive Scale	Week 1, Week 5, Week 10	A semi-structured clinician-administered instrument used to measure obsessions and compulsions separately over five dimensions (time consumed, distress, interference, degree of resistance, control). The range of scores for the Obsessions and Compulsions subscales is 0-20, and the range for the total score is 0-40. Higher scores indicate greater symptom severity, and a total score greater or equal to 16 is considered indicative of moderately severe OCD

Secondary Outcome Measures

Name	Time	Method
Obsessive Compulsive Inventory- Revised	Week 1, Week 5, Week 10	An 18-item self-report measure to assess obsessions and compulsions that demonstrates good psychometric properties and has been used in other research as a transdiagnostic measure of compulsivity. The range of scores for the six subscales (Washing; Obsessing; Ordering; Checking; Neutralizing; Hoarding) is 0-12. The range for the total score is 0-60 and does not include the Hoarding subscale. Higher scores indicate greater symptom severity.
Cambridge-Chicago Compulsivity Trait Scale	Week 1, Week 5, Week 10	A 15-item self-report measure to assess compulsivity transdiagnostically that exhibits high internal consistency and excellent convergent validity with gold-standard measures of compulsive symptoms. The range for the total score is 0-45, with higher scores indicating greater symptom severity
Self-Report Habit Index	Week 1, Week 5, Week 10	A 12-item self-report measure of the repetition and automaticity of a behavior that exhibits high internal consistency and test-retest reliability. The range for the total score is 12-84, with higher scores indicating greater symptom severity.
Dimensional Obsessive- Compulsive Scale	Week 1, Week 5, Week 10	A 20-item self-report measure that assesses four of the most consistently replicated thematic dimensions of OCD symptoms (i.e., contamination, harm, symmetry, repugnant content). The DOCS demonstrates good to excellent internal consistency, validity, and sensitivity. The range of scores for the four subscales (Contamination; Harm; Unacceptable Thoughts; Symmetry) is 0-20, and the range for the total score is 0-80. Higher scores indicate greater symptom severity.

Trial Locations

Locations (1)

Icahn School of Medicine at Mount Sinai; 🇺🇸 New York, New York, United States