Relationship Between Analgesia Nociception Index, Anxiety, and Pain in Conscious Hernia Patients Undergoing Combined Spinal Epidural Anesthesia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Combined Spinal-epidural Anesthesia
- Sponsor
- Beijing Chao Yang Hospital
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- The correlation between ANI and pain (measured with Visual Analog Scale,VAS), ANI and anxiety (measured with Visual Analog Scale-Anxiety,VAS-A) changes in conscious patients during anesthesia procedures
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Analgesia Nociception Index can be used to detect noxious stimulation during general anesthesia.The aim of this study is to observe ANI under combined spinal epidural anesthesia procedures in conscious hernia patients.
Detailed Description
Analgesia Nociception Index which is derived by heart rate variability, can be used to detect noxious stimulation during general anesthesia. However, the impact of anxiety on ANI evaluation and the correlation between ANI, pain, and anxiety in awake patients remains unclear. This study aimed to investigate the correlation between ANI, pain, and anxiety in conscious hernia patients undergoing combined spinal epidural anesthesia procedures.
Investigators
Changwei Wei
Deputy chief physician
Beijing Chao Yang Hospital
Eligibility Criteria
Inclusion Criteria
- •Age between 18- 80 years
- •ASA physical status I or II
- •Scheduled for inguinal hernia, umbilical hernia or incisional repair under CSEA
- •Written informed consent
Exclusion Criteria
- •Use of CNS-active medication or abuse of alcohol
- •History of cardiac arrhythmia
- •Contraindications of combined spinal epidural anesthesia
- •Previous exposure to CSEA or surgery
Outcomes
Primary Outcomes
The correlation between ANI and pain (measured with Visual Analog Scale,VAS), ANI and anxiety (measured with Visual Analog Scale-Anxiety,VAS-A) changes in conscious patients during anesthesia procedures
Time Frame: The changes of ANI, VAS, and VAS-A, from baseline at different Time-points to 2min after anesthesia procedures, (Timepoints: T1=after lateral position, T2=local anesthesia, T3=epidural needle puncture, and T4=2 minutes after puncture)
ANI is derived from hear rate variability, ranging from 0-100, bigger number means better analgesic level. Patients undergoing CSEA may experience mid-level anxiety while remaining conscious. The anxiety (VAS-A), pain (VAS), and ANI assessments were conducted at four specific time points.
Secondary Outcomes
- The correlation between pain (measured with Visual Analog Scale,VAS) and anxiety (measured with Visual Analog Scale-Anxiety,VAS-A) changes in conscious patients during anesthesia procedures(The changes of VAS, and VAS-A, from baseline at different Time-points to 2min after anesthesia procedures, (Timepoints: T2=local anesthesia, T3=epidural needle puncture, and T4=2 minutes after puncture))