A study of analgesic nociception index-guided requiring a dose of remifentanil during mechanical ventilatory support under continuous sedation in the intensive care unit
Not Applicable
- Conditions
- Postoperative patients required mechanical ventilatory support under continuous sedation in the intensive care unit
- Registration Number
- JPRN-UMIN000051696
- Lead Sponsor
- Ehime university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
Patients are 18 years old or less, underwent previous cardiac surgery, have severe arrhythmia, atrial fibrillation, and an implanted pacemaker, require high doses of catecholamines, or take some opioid medications preoperatively.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The total dose of remifentanil administered between admission to the intensive care unit and the next morning
- Secondary Outcome Measures
Name Time Method The mean score of HFVI, Total dose of sedative agents, The frequency of analgesics required after the termination of mechanical ventilatory support, VAS sore after the termination of mechanical ventilatory support, The development of delirium after the termination of mechanical ventilatory support, The cut-off value of HFVI score for BPS >5
Related Research Topics
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What molecular mechanisms underlie remifentanil's analgesic effects in ICU sedation for postoperative patients with mechanical ventilation?
How does analgesic nociception index-guided remifentanil dosing compare to standard-of-care sedation protocols in ICU mechanically ventilated postoperative patients?
Are there specific biomarkers that correlate with optimal remifentanil dosing in postoperative ICU patients requiring mechanical ventilation?
What are the potential adverse events associated with analgesic nociception index-guided remifentanil administration in critically ill postoperative patients?
What combination therapies or alternative analgesics are being explored alongside remifentanil for postoperative ICU patients on mechanical ventilation?