Targeted Memory Reactivation to augment TRAUMA therapy during sleep (TMR-TRAUMA study)

VU Medical Center and GGZ inGeest0 个研究点目标入组 48 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Current bipolar disorder, psychotic disorder, alcohol orsubstance use disorder (moderate and severe forms) as assessed with the M.I.N.I. International Neuropsychiatric Interview. Note comorbid depressive or anxiety disorders will be allowed if PTSD is present as diagnosis.
•Impossibility to isolate a circumscribed traumatic memory that can be used for the audioscript and for target selection in EMDR.
•Reactivation of the traumatic memory that is used for the audioscript and for target selection in EMDR, leads to severe dissociative complaints/signs”
•Not speaking/understanding Dutch sufficiently
•Active suicidal ideation
•Major head trauma with co-occurring loss of consciousness in the recent past
•(Neurological) disorder of the central nervous system, current or in history
•MRI contraindications such as metal implants, claustrophobia, pregnancy
•Use of psychotropic medication (other than benzodiazepines or other sleep medication), except when on a stable dose for at least 6 weeks (after start or alteration of dosage). Use of benzodiazepines or other sleep medication in the period of 1 week prior to study until end of study (Day 10).
•Use of recreational drugs over the entire study period (Day -7 to Day 10).
•Use of alcohol during Day -7, Day 1, Night 1, Day 2, Night 2, Day 3 and Day 10.
•Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel)
•A sleep window outside 10 pm and 10 am
•Sleep walking or REM sleep behaviour disorder

发起方

VU Medical Center and GGZ inGeest