NL-OMON28871
Recruiting
Not Applicable
Targeted Memory Reactivation to augment TRAUMA therapy during sleep (TMR-TRAUMA study)
VU Medical Center and GGZ inGeest0 sites48 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- VU Medical Center and GGZ inGeest
- Enrollment
- 48
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •PTSD diagnosis according to DSM\-5 criteria as assessed with the CAPS\-5
- •PTSD as primary diagnosis
Exclusion Criteria
- •Current bipolar disorder, psychotic disorder, alcohol orsubstance use disorder (moderate and severe forms) as assessed with the M.I.N.I. International Neuropsychiatric Interview. Note comorbid depressive or anxiety disorders will be allowed if PTSD is present as diagnosis.
- •Impossibility to isolate a circumscribed traumatic memory that can be used for the audioscript and for target selection in EMDR.
- •Reactivation of the traumatic memory that is used for the audioscript and for target selection in EMDR, leads to severe dissociative complaints/signs”
- •Not speaking/understanding Dutch sufficiently
- •Active suicidal ideation
- •Major head trauma with co\-occurring loss of consciousness in the recent past
- •(Neurological) disorder of the central nervous system, current or in history
- •MRI contraindications such as metal implants, claustrophobia, pregnancy
- •Use of psychotropic medication (other than benzodiazepines or other sleep medication), except when on a stable dose for at least 6 weeks (after start or alteration of dosage). Use of benzodiazepines or other sleep medication in the period of 1 week prior to study until end of study (Day 10\).
- •Use of recreational drugs over the entire study period (Day \-7 to Day 10\).
Outcomes
Primary Outcomes
Not specified
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