Follow-up study to evaluate the role of circulating cell-derived extracellular vesicles (EVs) in polytrauma

Not Applicable

Recruiting

• Conditions: T07; Unspecified multiple injuries

• Registration Number: DRKS00026025
• Lead Sponsor: Bundeswehrzentralkrankenhaus Koblenz

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Trauma patient with ISS >9

Exclusion Criteria

No declaration of consent, pregnancy, participants unter 18 years old, doubts about the patient's ability to consent or signs of dementia, as well as incomplete blood collection series. In addition, patients with acute or chronic inflammation, e.g., autoimmune hepatitis, but also genetic diseases, cholestatic diseases, and patients with co-infection, such as HCV and HBV or HCV and HIV, are excluded, as these have been shown to alter the fibrolytic EV profile.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate a) whether the severity of trauma can be assessed by EV signature (correlation with ISS) and b) whether polytrauma patients with internal organ damage can be differentiated from polytrauma patients without internal organ damage.

Secondary Outcome Measures

Name	Time	Method
The secondary question will investigate whether and, if so, which changes the concentrations of the above-mentioned EVs exhibit over time.