ANGIO-EX study: to determine whether the blood circulating protein angiopoietin like-2 (angptl2) is associated with a poor vessel health in young and old healthy volunteers, patients with a coronary artery heart disease and in obese subjects

Not Applicable

Completed

• Conditions: Aging and age-related cardiovascular diseases; Circulatory System; Cardiovascular disease, unspecified

• Registration Number: ISRCTN46169845
• Lead Sponsor: Montreal Heart Institute (Canada)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02-27
• Last Update Posted: 6 February 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

In phase 1, two groups (n=20 each) of healthy and physically trained volunteer members (men and women) of aged 18 to 39 years and 50 to 70 years.
Obese subjects (n=20) aged 50 to 70 years, men and women.
Healthy subjects are defined as men and women without cardiac, pulmonary or muscular diseases.
Obese patients are recruited at a BMI >30 kg/m2, without cardiac, pulmonary and muscular disease.

In phase 2 of the study, newly referred patients with CHD (n=20) aged 50 to 70 years, and obese subjects (n=20) aged 50 to 70 years, men and women.

Inclusion criteria for CHD patients are:
1. Documented prior acute coronary syndrome
2. Documented coronary revascularization or documented myocardial ischemia or necrosis on myocardial scintigraphy.

Obese patients are recruited at a BMI >30 kg/m2, without cardiac, pulmonary and muscular disease.

Exclusion Criteria

Active smokers (=1 cigarette per day) are excluded.

Exclusion criteria for healthy subjects:
1. Dyslipidemia (total cholesterol > 5.20 mM
2. HDL < 1.04 mM
3. LDL > 2.60 mM
4. Triglycerides > 1.7 mM or use of lipid-lowering therapy)
5. Hypertension (SBP >140 or DBP >90 mmHg or use of antihypertensive medications)
6. Treated or untreated diabetes mellitus
7. Impaired fasting glucose (>5.6 mM)
8. Overweight or obesity (BMI>25 kg/m2)
9. Abdominal obesity (waist circumference >90 cm in men, 80 cm in women)
10. Documented CHD (prior acute coronary syndrome, prior coronary revascularization, presence of myocardial ischemia or necrosis on myocardial scintigraphy), and for any other contraindication to exercise testing/training.

Exclusion criteria for CHD patients are:
1. Recent acute coronary event (within one month of inclusion)
2. History of exercise-induced or severe arrhythmias, unstable angina, pacemaker or defibrillator, presence of a pulmonary or skeletal muscle disease limiting maximal exercise testing/training
3. Body mass index (BMI) >28 kg/m2.

Exclusion criteria for obese subjects is the presence of a pulmonary or skeletal muscle disease limiting maximal exercise testing/training.

Study & Design

• Study Type: Interventional
• Study Design: Not specified