Factors Associated With Extubation Failure in Kanigara ICU (Intensive Care Unit) RSUPN Dr. Cipto Mangunkusumo

Completed

• Conditions: Extubation Failure; Ventilated Patients

• Registration Number: NCT07038291
• Lead Sponsor: Indonesia University

Brief Summary

Extubation is the final stage after patients undergo weaning procedure from mechanical ventilation in the ICU. Extubation failure followed by reintubation is associated with worse patient outcomes, including prolonged length of stay, increased risk of pulmonary infections, need for tracheostomy, higher healthcare costs, and increased mortality. Careful evaluation of various risk factors for extubation failure must be considered, therefore the extubation readiness guideline or checklist is essential before making the decision to extubate. This study aimed to identify factors associated with extubation failure in Kanigara ICU patients. This was a case-control study using secondary data from medical records of ICU patients who underwent extubation between January 2021 until August 2024. Variables analyzed included Glasgow Coma Scale (GCS) score, Arterial Blood Gas (ABG) results, hemodynamics, ventilator settings, airway protection ability, fluid balance, and airway-related problems. Bivariate and multivariate using logistic regression analyses were conducted to identify factors associated with extubation failure.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-03-01
• Primary Completion: 2025-05-30
• Status Verified: 2025-06
• Study Completion: 2025-06-05
• Study First Submitted: 2025-06-10
• Study First Submitted QC: 2025-06-17
• Last Update Submitted: 2025-06-17
• Study First Posted: 2025-06-26
• Last Update Posted: 2025-06-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 156

Inclusion Criteria

• Patient age 18 years old or more were intubated in Kanigara ICU RSCM more than 24 hours

Exclusion Criteria

• Dead or needed tracheostomy before extubation, or reintubated for surgical procedure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Factors Associated with Extubation Failure analyzed using logistic regression analysis	From January 2021 to August 2025	Factors assessed were GCS score, hemodynamics, fluid balance, BGA results, airway protection ability, and airway related problems. Data were taken from medical records.

Trial Locations

Locations (1)

RSUPN Dr. Cipto Mangunkusumo; 🇮🇩 Jakarta Pusat, DKI Jakarta, Indonesia