Can Increased Dietary Protein Prevent the Suppression of Metabolism and Maintain Anabolic Sensitivity of Bone and Skeletal Muscle During Caloric Restriction?
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Change in Circulating IGF-1
Study Overview
Brief Summary
The purpose of this study is to determine if an increased protein intake can attenuate the suppression of metabolic and anabolic hormones during caloric restriction
Detailed Description
- Preliminary testing
Prior to the study start, participants will be weighed and body composition will be determined using calipermetry (7 sites) and bioelectrical impedance. Peak oxygen uptake (VO2peak) will be assessed using an incremental exercise test on a bicycle ergometer. 2. Randomization
Participants will proceed through each of the following conditions lasting 5 days:
CR-LP: Participants will be restricted to 30 kcal/kg FFM/day and protein intake will be low (0.8 g/kg BW/day).
CR-HP: Participants will be restricted to 30 kcal/kg FFM/day and protein intake will be high (1.7 g/kg BW/day).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 19 Years to 30 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •4 hours/week of purposeful aerobic exercise over the last 3 months
- •Body mass index: 19-25 kg/m2
- •< 15% body fat
Exclusion Criteria
- •Cardiovascular disease risk factors that would result in greater than low risk
- •Type I, type II diabetes, or history of high fasting glucose;
- •History of high blood pressure and/or use of medication for hypertension;
- •History of Dyslipidemia, or on lipid-lowering medication;
- •Underlying health condition and/or use of medication that could interfere with any of our study outcomes.
- •History or current diagnosis of a clinical eating disorder
- •Failure to adhere to study protocol
Arms & Interventions
Caloric Restriction and High Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 1.7 g protein/kg BW/day.
Intervention: Caloric Restriction (Other)
Caloric Restriction and High Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 1.7 g protein/kg BW/day.
Intervention: Protein (Other)
Caloric Restriction and High Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 1.7 g protein/kg BW/day.
Intervention: Exercise (Other)
Caloric Restriction and Normal Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 0.8 g protein/kg BW/day.
Intervention: Caloric Restriction (Other)
Caloric Restriction and Normal Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 0.8 g protein/kg BW/day.
Intervention: Exercise (Other)
Energy Balance
Participants will be in energy balance and consume 1.7 g protein/kg BW/day.
Intervention: Protein (Other)
Energy Balance
Participants will be in energy balance and consume 1.7 g protein/kg BW/day.
Intervention: Exercise (Other)
Caloric Restriction and Normal Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 0.8 g protein/kg BW/day.
Intervention: Maltodextrin (Other)
Energy Balance
Participants will be in energy balance and consume 1.7 g protein/kg BW/day.
Intervention: Maltodextrin (Other)
Energy Balance
Participants will be in energy balance and consume 1.7 g protein/kg BW/day.
Intervention: Calcium and Vitamin D (Dietary Supplement)
Caloric Restriction and Normal Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 0.8 g protein/kg BW/day.
Intervention: Calcium and Vitamin D (Dietary Supplement)
Caloric Restriction and High Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 1.7 g protein/kg BW/day.
Intervention: Maltodextrin (Other)
Caloric Restriction and High Protein
Participants will be calorie restricted to 30 kcal/kg FFM/day and consume 1.7 g protein/kg BW/day.
Intervention: Calcium and Vitamin D (Dietary Supplement)
Outcomes
Primary Outcomes
Change in Circulating IGF-1
Time Frame: Baseline and day 6
Change in Resting Metabolic Rate
Time Frame: Baseline and day 6
Change in Marker of Bone Formation (P1NP)
Time Frame: Baseline and day 6
Change in Marker of Bone Resorption (CTx)
Time Frame: Baseline and day 6
Secondary Outcomes
- Change in Perceived Hunger(Baseline and day 6)
- Change in Body Weight(Baseline and day 6)
- Change in Body Fat Percentage(Baseline and day 6)
- Change in Aerobic Fitness (VO2peak)(Baseline and day 6)