Lead Mobilization & Bone Turnover in Pregnancy/Lactation
Completed
- Conditions
- Lead Poisoning
- Registration Number
- NCT00011726
- Lead Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
- Brief Summary
We are examining the role of maternal bone lead turnover during pregnancy and lactation as a potential source of lead exposure for the fetus and the infant (via breast milk). A cohort, ascertained at entry to care, consists of \>1000 women to be followed through pregnancy. In the postpartum subjects are recruited for a nested case control study to assess the influence of lactation on maternal bone density, maternal blood lead and breast milk lead.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 1000
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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What molecular mechanisms link maternal bone lead turnover to fetal and infant lead exposure?
Are there specific biomarkers that correlate with maternal blood lead levels and breast milk lead excretion during lactation?
How does lactation-induced bone turnover compare to other bone resorption processes in terms of lead mobilization?
What are the long-term health outcomes for infants exposed to lead via maternal bone turnover during pregnancy and lactation?
What strategies are effective in managing maternal lead mobilization to reduce fetal and infant exposure?