Dietary Patterns and Variability in Blood Lead Concentrations Among Pregnant British Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,167
- 主要终点
- Blood lead concentration
研究概览
简要总结
During pregnancy lead crosses the placenta freely and can have adverse effects on the fetus, with the potential for life-long impact on the child. Identification of dietary patterns and food groups in pregnancy in relation to measures of lead status could provide a more useful alternative to a nutrient-specific advice to minimise fetal exposure to lead during pregnancy. The aim is to evaluate whether dietary patterns and food groups are associated with blood lead concentrations in pregnancy.
详细描述
Whole blood samples were collected from pregnant women enrolled in the Avon Longitudinal Study of Parents and Children observational birth cohort study and were analysed for lead. Dietary pattern scores were derived from principal components analysis of a food frequency questionnaire. Associations of quartiles of dietary pattern scores, and of food groups categorised by frequency of consumption, with the likelihood of blood lead concentration (B-Pb) ≥5 µg/dl will be identified with adjusted logistic regression (n=2167).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Enrolled in ALSPAC, pregnant -
排除标准
- •Not enrolled in ALSPAC, not pregnant
结局指标
主要结局
Blood lead concentration
时间窗: During gestation
Blood lead concentration
次要结局
未报告次要终点