Protein Tyrosine Kinases (PTK) in Multiple Myeloma

Phase 2

Completed

• Conditions: Multiple Myeloma

• Registration Number: NCT00165347
• Lead Sponsor: Dana-Farber Cancer Institute

Brief Summary

The purpose of this study is to determine whether or not cancer cells in the body are affected by PTK and whether it affects the growth of these cells.

Detailed Description

Patients will take PTK orally once a day for the duration of their time on the study. Each cycle of chemotherapy will last for 4 weeks.

Measurement of vital signs will be done weekly during the first month of treatment.

Physical exam, vital signs, blood work, a quality of life assessment, and x-ray or MRI wil be performed every 4 weeks.

Patients will remain on the study until their disease fails to respond to treatment or there are intolerable side effects. Typically treatment is performed for 12 weeks and up to one year in patients that are stable and responding.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2003-12
• Study First Submitted: 2005-09-09
• Study First Submitted QC: 2005-09-09
• Study First Posted: 2005-09-14
• Primary Completion: 2006-10
• Study Completion: 2006-10
• Status Verified: 2007-12
• Last Update Submitted: 2007-12-20
• Last Update Posted: 2007-12-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Older than 18 years of age.
• Confirmed diagnosis of active progressive multiple myeloma
• History of > 2 prior cytotoxic treatment regimens. Bone marrow transplantation will be considered as one regimen.
• Current measurable disease based on serum and/or urine M protein and/or measurable plasmacytoma.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
• Absolute neutrophil count (ANC) > 1,500 mm3
• Platelets > 100,000 mm3
• Serum creatinine < 1.5 upper limit of normal (ULN)
• Serum bilirubin < 1.5 ULN
• AST/AGOT and ALT/SGPT < 3.0 ULN
• Life expectancy > 12 weeks

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Exclusion Criteria

• Chemotherapy < 3 weeks prior to registration.
• Biologic or immunotherapy < 2 weeks prior to registration
• Full field radiotherapy < 4 weeks or limited field radiotherapy < 2 weeks prior to registration.
• History or presence of central nervous system (CNS) disease
• History of leukemia
• History of another primary malignancy with the exception of inactive basal or squamous cell carcinoma of the skin
• Major surgery < 4 weeks prior to registration
• Prior therapy with anti-vascular endothelial growth factor (VEGF) agents excluding thalidomide, Revimid, velcade and arsenic trioxide
• Interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung
• Pleural effusion or ascites that cause respiratory compromise
• Female patients that are pregnant or breast feeding
• Uncontrolled high blood pressure, history of labile hypertension or history of poor compliance with an antihypertensive regimen
• Unstable angina pectoris
• Symptomatic congestive heart failure
• Myocardial infarction < 6 months prior to registration
• Serious uncontrolled cardiac arrhythmia
• Uncontrolled diabetes
• Active or uncontrolled infection
• Acute or chronic liver disease
• Impairment of gastrointestinal (GI) function or GI disease
• Confirmed HIV infection

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
To determine the effectiveness of PTK in treating patients with relapsed or refractory myeloma

Secondary Outcome Measures

Name	Time	Method
to investigate the safety of PTK in patients with relapsed/refractory multiple myeloma
To evaluate the progression free survival of patients treated with PTK

Trial Locations

Locations (1)

Dana-Farber Cancer Institute; 🇺🇸 Boston, Massachusetts, United States