Assessment of triglyceride glucose BMI index with respect to coronary slow flow phenomenon in patients with acute myocardial infarction undergoing primary coronary intervention
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To study the relationship between triglyceride levels, glucose levels, and BMI with the coronary slow flow phenomenon in patients with acute myocardial infarction and are receiving primary coronary intervention.
研究概览
简要总结
This observational study aims to asses the association of triglyceride glucose BMI with coronary slow flow phenomenon in patients with acute myocardial infarction undergoing PPCI . All patients will undergo ECG examination, and only those with acute myocardial infarction undergoing PCI will be included. Clinical and electrocardiographic assessments will be made, including risk factors, vital signs, and presenting complaints. Laboratory tests (fasting glucose, total cholesterol, triglycerides, HDL-C, LDL-C) will be done using fasting blood samples. The TYG-BMI index will be calculated as [plasma triglycerides x fasting glucose / 2] x BMI. Diagnostic coronary angiography will identify the culprit vessel, TIMI flow, and thrombus burden. Angiographic thrombus burden will be classified by TIMI grades. 50 patients with TIMI less than ,equal to 2 and 50 with TIMI = 3 will be analyzed based on TYG-BMI. Patient management will follow standard care without intervention from the investigators.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 85.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of STEMI managed by PPCI and receiving the standard of care will be included in the study The diagnosis of STEMI established according to the universal definition of myocardial infarction as Typical rise of biochemical markers of myocardial necrosis with atleast one of the following 1)ischemic symptoms as chestpain or discomfort more than 20mins with in less than 24 hrs 2)ECG changes indicative of ischemia :new ST elevation at the J point in two contiguous leads 3)New onset LBBB 4)Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality.
排除标准
- •Patients on triglyceride lowering medications 2)History of Acute Myocardial infarction ,CABG or PCI 3)Valvular heart disease 4)Cardiomyopathy 5)Acute or chronic infection 6)Taking glucocorticoid therapy at the time of admission 7)Severe kidney and liver insufficiency (transaminase greater than or equal to two times the normal value ,GFR less than 15 ).
结局指标
主要结局
To study the relationship between triglyceride levels, glucose levels, and BMI with the coronary slow flow phenomenon in patients with acute myocardial infarction and are receiving primary coronary intervention.
时间窗: 1.5 years
次要结局
- study the association of triglyceride glucose BMI index with respect to coronary slow flow phenomenon(1.5 years)
研究者
Dr Kotharu Sai Sindhu
Kasturba Medical College,Manipal