Brain activity changes by magnetic stimulation on scalp

Phase 1

Recruiting

• Conditions: Parkinson's syndrome including Parkinson's disease, stroke, spinocerebellar degeneration; D010300; neurological disorders

• Registration Number: JPRN-jRCT1052210071
• Lead Sponsor: Koganemaru Satoko

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-12-03
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 320

Inclusion Criteria

Selection criteria
Adults who consent to participate in the study

Healthy subjects)
Those who have no history of psychiatric disorders and have sufficient understanding and consent.

Neurological disease patients)
Adult patients who consent to participate in the study and who are undergoing medical treatment at the outpatient department of neurology or inpatient department of Kyoto University Hospital. The target disease is Parkinson's syndrome including Parkinson's disease, stroke, or spinocerebellar degeneration. Adults with 20 years old and over (18 years old and over after April 1, 2022) are targeted, but no other age / gender criteria are set.

Exclusion Criteria

Exclusion criteria
Healthy subjects)
1 Those who do not give consent to participate in the study
2 Those who have a significant obstacle to communication
3 Those who are judged inappropriate as a participant by the Transcranial Magnetic Stimulation Test / Pre-Checklist and MR Test Pre-Checklist.
4 Those who are with claustrophobia

Neurological disease patients)
1 Those who are in a extremely poor general condition (such as abnormal vital signs)
2 Those who do not give consent for the research subject
3 Those who are judged inappropriate as a participant by the Transcranial Magnetic Stimulation Test / Pre-Checklist and MR Test Pre-Checklist.
4 Those who are with claustrophobia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Motor evoked potential by TMS

Secondary Outcome Measures

Name	Time	Method
Amplitude values in each frequency band of EEG, values measurted by structural and functional 7T-MRI to investigate connectivity between brain regions<br>Eye movement measurement