Effect of Anesthetic Agents (Propofol, Sevoflurane) on Optic Nerve Sheath Diameter(ONSD) in Patients Undergoing Robot-assisted Laparoscopic Gynecology Surgery
Overview
- Phase
- N/A
- Intervention
- Sevoflurane
- Conditions
- Uterus Myoma
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
- Enrollment
- 42
- Locations
- 1
- Primary Endpoint
- difference of optic nerve sheath diameter
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.
Detailed Description
Anesthetic agents (propofol and sevoflurane)have different effect on intracranial pressure. Sevoflurane when used over 0.5 minimum alveolar concentration, dilates intracranial vasculature and increases intracranial pressure. On the other hand, propofol decreases intracranial blood pressure and intracranial pressure is maintained or decreases. Optic nerve sheath diameter is a feasible diagnostic tool in evaluating intracranial pressure. Female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy are evaluated.
Investigators
Eligibility Criteria
Inclusion Criteria
- •female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy
Exclusion Criteria
- •history of brain hemorrhage or brain infarction
- •liver disease or end stage renal disease
- •glaucoma or any signs of increased intraocular pressure
- •combined wtih other types of operation
- •patient refusal
- •weight less than 40 kg or over 100 kg
Arms & Interventions
Sevoflurane
1.5-2.5 vol% of sevoflurane is used for maintenance of anesthesia.
Intervention: Sevoflurane
Propofol
2-5 mcg/ml of propofol is used continuously for maintenance of anesthesia using target-controlled infusion system.
Intervention: Propofol
Outcomes
Primary Outcomes
difference of optic nerve sheath diameter
Time Frame: During the operation.
optic nerve sheath diameter is measured using sonographic probe. (10 minutes after induction of anesthesia/ 5 minutes after pneumoperitoneum and trendelenburg position / 20 minutes after pneumoperitoneum and trendelenburg position / 40 minutes after pneumoperitoneum and trendelenburg position / skin closure)