The Effect of Propofol and Sevoflurane Anesthesia on Renal Function in Patients Undergoing Back Surgery
Overview
- Phase
- Phase 4
- Intervention
- Back Surgery
- Conditions
- Acute Kidney Injury
- Sponsor
- Uppsala University
- Enrollment
- 37
- Locations
- 1
- Primary Endpoint
- Change in urine output
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This study investigates the role of the anesthetic agents propofol and sevoflurane on renal function in otherwise healthy patients undergoing basic back surgery.
Detailed Description
Water-sodium homeostasis is central for anyone undergoing surgery, and can therefore affect surgical outcome, level of postoperative care and the length of hospital stay. Too much or too little fluid during surgery can affect the patients negatively. The kidneys play an imperative role in the regulation of water and sodium homeostasis, however there are lack of knowledge in how the anesthesia per se affects renal function. Previous studies have shown that volatile anesthetic agents such as sevoflurane can cause fluid retention. Why this happens is not completely known. We are now investigating the different affects of sevoflurane and propofol anesthesia on renal function in patients undergoing basic back surgery to elucidate if there is a difference in the risk of developing acute kidney injury.
Investigators
Robert Frithiof
MD PhD
Uppsala University
Eligibility Criteria
Inclusion Criteria
- •Scheduled back surgery
Exclusion Criteria
- •American Association of Anesthesiology class 1-3
- •American Heart Association class \>3
- •Insulin treated diabetes
- •Pregnancy or breast feeding
- •Sensistivity/allergy against anesthetic agents
- •Inadequate understanding about the study
- •Depressed kidney function and/or AKI
- •Depressed liver function
- •Genetic malignant hyperthermia
Arms & Interventions
Sevoflurane
Intervention Back surgery and sevoflurane.
Intervention: Back Surgery
Sevoflurane
Intervention Back surgery and sevoflurane.
Intervention: Sevoflurane
Propofol
Intervention Back surgery and propofol.
Intervention: Back Surgery
Propofol
Intervention Back surgery and propofol.
Intervention: Propofol
Outcomes
Primary Outcomes
Change in urine output
Time Frame: 24 hours
Urine output (ml/min) changes during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.
Change in serum creatinine levels
Time Frame: 24 hours
Changes in serum creatinine levels during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.
Change in creatinine clearance
Time Frame: 24 hours
Creatinine clearance changes during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.
Secondary Outcomes
- Changes in electrolytes(24 hours)
- Changes in hormone levels(24 hours)