Comparison of Effects of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia on Maternal and Fetal Outcomes After Cesarean Section
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Maternal hospital stay
研究概览
简要总结
Sevoflurane and propofol are the most popular drug choices for maintenance of general anaesthesia for caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly. The aim of this study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia, and to try to determine which anesthetic is better for maternal and fetal outcomes after caesarean section.
详细描述
General anaesthesia is mostly performed for emergency grade 1 caesarean section and due to a lack of time to apply a neuraxial anaesthesia technique. Rapid sequence induction using propofol and rocuronium should become the standard for general anaesthesia in the obstetric patient. Both sevoflurane and propofol are considered to be appropriate for the maintenance of general anaesthesia during caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly in the past. And for most anaesthesiologists, the clinical experience with general anaesthesia for caesarean section is very low. This study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASAⅠor Ⅱ parturients (aged 18-35 years) undergoing elective caesarean section
排除标准
- •Parturients with severe pregnancy complications
研究组 & 干预措施
propofol
干预措施: propofol (Drug)
sevoflurane
干预措施: sevoflurane (Drug)
结局指标
主要结局
Maternal hospital stay
时间窗: Before dismissed from hospital
Maternal hospital stay time
Maternal mortality
时间窗: Before dismissed from hospital
Maternal mortality in hospital
Newborn hospital stay
时间窗: Before dismissed from hospital
Newborn hospital stay time
Newborn mortality
时间窗: Before dismissed from hospital
Newborn mortality in hospital
次要结局
未报告次要终点
研究者
Tao Zhang
Clinical Professor of Department of Anesthesiology
First Affiliated Hospital, Sun Yat-Sen University