Comparison of Effects of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia on Maternal and Fetal Outcomes After Cesarean Section
Overview
- Phase
- Phase 4
- Intervention
- propofol
- Conditions
- Sevoflurane
- Sponsor
- Tao Zhang
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Maternal hospital stay
- Last Updated
- 7 years ago
Overview
Brief Summary
Sevoflurane and propofol are the most popular drug choices for maintenance of general anaesthesia for caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly. The aim of this study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia, and to try to determine which anesthetic is better for maternal and fetal outcomes after caesarean section.
Detailed Description
General anaesthesia is mostly performed for emergency grade 1 caesarean section and due to a lack of time to apply a neuraxial anaesthesia technique. Rapid sequence induction using propofol and rocuronium should become the standard for general anaesthesia in the obstetric patient. Both sevoflurane and propofol are considered to be appropriate for the maintenance of general anaesthesia during caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly in the past. And for most anaesthesiologists, the clinical experience with general anaesthesia for caesarean section is very low. This study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia.
Investigators
Tao Zhang
Clinical Professor of Department of Anesthesiology
First Affiliated Hospital, Sun Yat-Sen University
Eligibility Criteria
Inclusion Criteria
- •ASAⅠor Ⅱ parturients (aged 18-35 years) undergoing elective caesarean section
Exclusion Criteria
- •Parturients with severe pregnancy complications
Arms & Interventions
propofol
Intervention: propofol
sevoflurane
Intervention: sevoflurane
Outcomes
Primary Outcomes
Maternal hospital stay
Time Frame: Before dismissed from hospital
Maternal hospital stay time
Maternal mortality
Time Frame: Before dismissed from hospital
Maternal mortality in hospital
Newborn hospital stay
Time Frame: Before dismissed from hospital
Newborn hospital stay time
Newborn mortality
Time Frame: Before dismissed from hospital
Newborn mortality in hospital