Effects of Propofol and Sevoflurane on Early Postoperative Cognitive Dysfunction in Elderly Patients With Metabolic Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Complications
- Sponsor
- General Hospital of Ningxia Medical University
- Enrollment
- 94
- Primary Endpoint
- Number of participants with Postoperative cognitive dysfunction (POCD) as assessed by Mini-Mental State Examination (MMSE) score in propofol group and sevoflurane group
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.
Detailed Description
By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.
Investigators
Eligibility Criteria
Inclusion Criteria
- •aged ≥60 years;
- •noncardiac surgery and nonneural surgery
Exclusion Criteria
- •Mini Mental State Examination \[MMSE\] score too low
- •chronic alcoho and drug abuse
- •disturbed renal and liver function
- •history of a cerebrovascular accident
- •permanent ventricular pacing
- •preoperative cognitive deficits
- •lack of cooperation
Outcomes
Primary Outcomes
Number of participants with Postoperative cognitive dysfunction (POCD) as assessed by Mini-Mental State Examination (MMSE) score in propofol group and sevoflurane group
Time Frame: up to 7days postoperatively