Postoperative Effects of Propofol Versus Sevoflurane Anesthesia During Elective Non-Cardiac Surgeries. A Randomized Clinical Trial
Overview
- Phase
- Phase 4
- Intervention
- Propofol 10 MG/ML Injection
- Conditions
- General Anesthetic Drug Adverse Reaction
- Sponsor
- Damanhour Teaching Hospital
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- Mean and Standard deviation of Neuron Specific Enolase enzyme (µg/L) in blood serum (mean±SD)
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life.
Objectives: To compare the efficacy and safety of propofol versus sevoflurane in patients undergoing elective, non-cardiac operations under general anesthesia.
Methods: This was a randomized (1:1), parallel, phase four clinical trial; carried out on 44 patients, who were candidates for elective, non-cardiac operations under general anesthesia at our hospital. Patients were randomly allocated into two equal groups in which anesthesia was maintained with propofol infusion in group P and sevoflurane inhalation in group S.
Investigators
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) physical status ≤ II
- •Age from 21 years
- •Body Mass Index (BMI) 25-35 kg/m2
Exclusion Criteria
- •ASA physical status \> II
- •Age \< 21 years
- •Patients with Montreal Objective Cognitive Assessment (MoCA-B) score \< 24 points
- •Patients with significant cardiovascular, cerebrovascular, respiratory, liver, renal, endocrine, blood, or immune diseases
- •Patients with visual or auditory disease, infection, chronic inflammation, disturbance of consciousness, cognitive impairment, or dementia
- •Patients on long-term use of sedatives or steroids, alcohol or drug abuse
- •Allergy to any of the study drugs
Arms & Interventions
Group P (n=22)
Propofol group
Intervention: Propofol 10 MG/ML Injection
Group S (n=22)
Sevoflurane group
Intervention: Sevoflurane Inhalation Liquid
Outcomes
Primary Outcomes
Mean and Standard deviation of Neuron Specific Enolase enzyme (µg/L) in blood serum (mean±SD)
Time Frame: 24 hours after the end of operation
Before operation (T0), 1 hour after the end of operation (T1), 24 hours the end of operation (T2)