Effect of Propofol and Sevoflurane on Postoperative Catheter-Related Bladder Discomfort
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- Catheter-related Bladder Discomfort
研究概览
简要总结
The investigators want to evaluate the efficacy of the propofol and sevoflurane for the prevention of catheter-related bladder discomfort.
详细描述
The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. Propofol and desflurane are most widely used as an anesthetic agent. Propofol and desflurane are known to block the muscarinic receptor in different ways.
The investigators want to evaluate the efficacy of the propofol and sevoflurane for the prevention of catheter-related bladder discomfort.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for transurethral bladder excision under general anesthesia
- •ASA I-III
排除标准
- •Foley catheter less than 18 Fr.
- •Patients with obstruction of urinary tract
- •Patients with neurogenic bladder
- •Patients with severe obesity
- •Patients with neurologic disorder
- •Patients with chronic pain
- •Patients with allergic history to propofol or sevoflurane
研究组 & 干预措施
Propofol
Propofol will be administered as the anesthetic maintenance agent.
干预措施: Propofol (Drug)
Sevoflurane
Sevoflurane will be administered as the anesthetic maintenance agent.
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Catheter-related Bladder Discomfort
时间窗: 1 hour postoperatively
Catheter-related bladder discomfort will be measured at 1 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe). Patients with score \>0 will be counted.
次要结局
- Blurred Vision(0, 1, 6 and 24 hour postoperatively)
- Dry Mouth(0, 1, 6 and 24 hour postoperatively)
- Flushing(0, 1, 6 and 24 hour postoperatively)
- Dizziness(0, 1, 6 and 24 hour postoperatively)
- Catheter-related Bladder Discomfort(0, 6 and 24 hour postoperatively)
- Hemodynamic Parameters(0, 1, 5, 10 minute postoperatively)
- Nausea(0, 1, 6 and 24 hour postoperatively)
- Vomiting(0, 1, 6 and 24 hour postoperatively)
- Analgesics(0, 1, 6 and 24 hour postoperatively)