NL-OMON23610
Recruiting
Not Applicable
Skeletal muscle glucose transport and mitochondrial function in type 1 diabetes
ConditionsType 1 diabetes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Type 1 diabetes
- Sponsor
- Vrije Universiteit Amsterdam
- Enrollment
- 32
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •In order to be eligible to participate in this study, participants with T1DM must meet all of the following criteria:
- •Individuals with T1DM with a diagnosed disease duration of 1 – 45 years
- •Male or female
- •Aged between 18\-65 years
- •In order to be eligible to participate in this study, healthy control participants must meet all of the following criteria:
- •No chronic health conditions and between the ages of 18\-65
Exclusion Criteria
- •History of asthma, stroke, chronic obstructive pulmonary disease, congestive heart failure, heart surgery, or congenital heart diseases
- •Current treatment with drugs known to interfere with metabolism e.g. systemic corticosteroids, statins, SGLT2 inhibitors, GLP1 receptor agonists
- •Are current smokers or have been a regular smoker within the last 12 months
- •Insulin pump therapy
- •Symptomatic autonomic or distal neuropathy
- •BMI \>30 due to adiposity, since this is known to cause difficulties in obtaining muscle biopsies.
- •Recent acute myocardial infarction (\<6 months)
- •Uncontrolled arrhythmia/severe conduction disorder (atrial fibrillation or second/third degree AV block) causing hemodynamic compromise
- •Implantable pacemaker or other cardiac device with complete ventricular pacing
- •Uncontrolled heart failure with hemodynamic compromise
Outcomes
Primary Outcomes
Not specified
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