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Clinical Trials/NL-OMON39110
NL-OMON39110
Completed
Not Applicable

Skeletal muscle mitochondrial (dys)function in humans: Relating macroscopic in vivo observations to mechanistic understanding at molecular scale - systems biology of mitochondrial dysfunction

Maxima Medisch Centrum0 sites52 target enrollmentTBD
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Conditionsveroudering, mitochondriële myopathieagingdiabetes10012653

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
veroudering, mitochondriële myopathie
Sponsor
Maxima Medisch Centrum
Enrollment
52
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Observational invasive

Investigators

Sponsor
Maxima Medisch Centrum

Eligibility Criteria

Inclusion Criteria

  • •All subjects:
  • •\- written informed consent;Mitochondrial myopathy:
  • •\- patients diagnosed with mitochondrial myopathy
  • •\- Age: 18\+;Type 2 diabetes:
  • •\- patients diagnosed with Type 2 diabetes for at least 2 years
  • •\- age: 18\+
  • •\- BMI 26 \- 42 kg/m2
  • •\- sedentary behaviour as confirmed by a questionnaire asking about physical activity levels
  • •\- sex: male
  • •Elderly with sedentary lifestyle:

Exclusion Criteria

  • •All subjects:
  • •\- pacemaker / implantable cardioverter defibrillator (ICD)
  • •\- metal prostheses
  • •\- implanted devices
  • •\- vascular clips
  • •\- profession (current of in the past) as welder or metalworker (risk of small metal fragments in eyes);\- claustrophobia
  • •\- use of oral anti\-coagulants
  • •\- use of inorganic nitrate
  • •\- cardio\-vascular disease (decompensatio cordis, agina pectoris, myocardial infarction of positive signs of cardiac ischaemia on the ECG during the incremental exercise test on the bicycle ergometer)
  • •\- cerebro\-vascular disease (CVA)

Outcomes

Primary Outcomes

Not specified

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