Skeletal muscle mitochondrial (dys)function in humans: Relating macroscopic in vivo observations to mechanistic understanding at molecular scale - systems biology of mitochondrial dysfunction

Maxima Medisch Centrum0 个研究点目标入组 52 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•All subjects:
•- written informed consent;Mitochondrial myopathy:
•- patients diagnosed with mitochondrial myopathy
•- Age: 18+;Type 2 diabetes:
•- patients diagnosed with Type 2 diabetes for at least 2 years
•- age: 18+
•- BMI 26 - 42 kg/m2
•- sedentary behaviour as confirmed by a questionnaire asking about physical activity levels
•- sex: male
•Elderly with sedentary lifestyle:
•- Age: 50 - 75 yrs
•- sedentary lifestyle as confirmed by a questionnaire asking about physical activity levels
•- sex: male ;Elderly with active lifestyle:
•- Age: 50 - 75 yrs
•- active lifestyle as confirmed by a questionnaire asking about physical activity levels
•- sex: male
•Control subjects:
•- Age: 20 - 30 yrs
•- BMI: 20 - 25
•- Normally active lifestyle as confirmed by a questionnaire asking about physical activity levels
•- sex: male

•All subjects:
•- pacemaker / implantable cardioverter defibrillator (ICD)
•- metal prostheses
•- implanted devices
•- vascular clips
•- profession (current of in the past) as welder or metalworker (risk of small metal fragments in eyes);- claustrophobia
•- use of oral anti-coagulants
•- use of inorganic nitrate
•- cardio-vascular disease (decompensatio cordis, agina pectoris, myocardial infarction of positive signs of cardiac ischaemia on the ECG during the incremental exercise test on the bicycle ergometer)
•- cerebro-vascular disease (CVA)
•- neurological diseases of deficits
•- vascular complications

发起方

Maxima Medisch Centrum