NL-OMON53341
Not yet recruiting
Not Applicable
MUSCLE study - Mitochondrial dysfUnction: a key player in doxorubicin-induced Skeletal and Cardiac muscLE damage? - MUSCLE
niversitair Medisch Centrum Utrecht0 sites12 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Non-Hodgkin lymphoma
- Sponsor
- niversitair Medisch Centrum Utrecht
- Enrollment
- 12
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \>\= 18 years
- •Patients with large B\-cell lymphoma or T\-cell lymphoma scheduled for 6
- •full\-dose cycles of 1st line immunochemotherapy with cyclophosphamide,
- •doxorubicin, vincristine and prednisone with or without rituximab ((reversed)
- •(R\-)CHOP).
- •WHO\-performance score 0\-2\.
- •Patients with sufficient Dutch writing and reading skills.
- •Written informed consent
Exclusion Criteria
- •Contra\-indications for 7T MR scanning
- •Any circumstances that would impede adherence to study requirements or
- •ability to give informed consent.
- •Medical disorders affecting mitochondrial function; e.g., spinal muscular
- •(Other) relevant medical disorders; e.g., comorbidities affecting exercise
- •Being under examination for non\-diagnosed disease at the time of
- •investigation.
Outcomes
Primary Outcomes
Not specified
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