Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Mitochondrial respiratory chain enzyme activity
Study Overview
Brief Summary
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients. Secondary aims are to clarify the pathogenesis and the clinical relevance of mitochondrial damage during sepsis.
Detailed Description
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients, as compared to otherwise healthy surgical ones. In order to better clarify the pathogenesis of mitochondrial dysfunction during sepsis, cardiogenic shock patients (suffering from systemic hypoperfusion) will act as additional controls. Markers of oxidative stress will be measured in tissue samples from septic patients. The clinical relevance of mitochondrial dysfunction during sepsis will be assessed in terms of both skeletal muscle and platelet function.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Consecutive ICU-admitted severely septic or septic shock patients.
Exclusion Criteria
- •Severe thrombocytopenia.
- •Severe coagulopathy.
- •Pre-existing mitochondrial disease
Outcomes
Primary Outcomes
Mitochondrial respiratory chain enzyme activity
Time Frame: On day one and seven from admission to ICU
Secondary Outcomes
No secondary outcomes reported