Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
- Conditions
- Septic ShockSevere Sepsis
- Registration Number
- NCT00541827
- Brief Summary
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients. Secondary aims are to clarify the pathogenesis and the clinical relevance of mitochondrial damage during sepsis.
- Detailed Description
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients, as compared to otherwise healthy surgical ones. In order to better clarify the pathogenesis of mitochondrial dysfunction during sepsis, cardiogenic shock patients (suffering from systemic hypoperfusion) will act as additional controls. Markers of oxidative stress will be measured in tissue samples from septic patients. The clinical relevance of mitochondrial dysfunction during sepsis will be assessed in terms of both skeletal muscle and platelet function.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- Consecutive ICU-admitted severely septic or septic shock patients.
- Severe thrombocytopenia.
- Severe coagulopathy.
- Pre-existing mitochondrial disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mitochondrial respiratory chain enzyme activity On day one and seven from admission to ICU
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena
🇮🇹Milan, Italy