Lidocaine 5% Patch Supplementation to Intra-articular Bupivacaine Dexmedetomidine After Arthroscopic Knee Surgery

Not Applicable

Completed

• Conditions: Dexmedetomidine; Lidocaine 5% Patch; Arthroscopic Knee Surgery; Intra-articular
• Interventions: Drug: Dexmedetomidine Bupivacaine; Drug: Lidocaine 5% patch with Dexmedetomidine Bupivacaine

• Registration Number: NCT04322760
• Lead Sponsor: Tanta University

Brief Summary

Surgery of the knee is a very common procedure which can be very painful and sufficient postoperative pain treatment is often problematic. The aim of this work was to study the effects of supplementation of intra-articular bupivacaine dexmedetomidine with lidocaine 5% patch after arthroscopic knee surgery under general anesthesia and its role in improving quality of anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12-01
• Primary Completion: 2017-11-30
• Study Completion: 2017-12-01
• Status Verified: 2020-03
• Study First Submitted: 2020-03-24
• Study First Submitted QC: 2020-03-25
• Last Update Submitted: 2020-03-25
• Study First Posted: 2020-03-26
• Last Update Posted: 2020-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Adult patients
• ASA I & II
• Aged between 18 to 60 years
• Weight between 60 to 100 kg
• Scheduled for elective arthroscopic knee surgery

Exclusion Criteria

• patient refusal.
• history of cardiac disease.
• impaired renal or hepatic function.
• hypertension treated with α methyldopa, clonidine, or beta-adrenergic blockers.
• if they have used opioid analgesics within the previous 24 hr.
• previous sensitivity to local anesthetics.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A (control group)	Dexmedetomidine Bupivacaine	Patients in each received 10 ml 0.5 % bupivacaine and 1µg/kg dexmedetomidine diluted in 10 ml saline injected intra-articularly without lidocaine patch
Group B	Lidocaine 5% patch with Dexmedetomidine Bupivacaine	Patients in each received 10 ml 0.5 % bupivacaine and 1µg/kg dexmedetomidine diluted in 10 ml saline injected intra-articularly with a patch of lidocaine 5% was applied to the skin

Primary Outcome Measures

Name	Time	Method
The total dose of postoperative pethidine consumption	24 hours	The total dose of postoperative pethidine consumption; Pethidine 20 mg was given as rescue analgesia if pain visual analogue visual analogue scale (VAS) ≥4.

Secondary Outcome Measures

Name	Time	Method
First postoperative analgesia request time	24 hours	First postoperative analgesia (Pethidine 20 mg) request time
Pain intensity	24 hours	Visual analogue scale (VAS) was recorded immediately postoperative and at 30 min, 1, 2, 4, 6, 12 and 24 hours postoperatively. The score ranges from 0 to 10; higher means worse pain