Evaluation of the Effect of Calcitriol on the Percutaneous Coronary Interventio
Phase 3
- Conditions
- Percutaneous coronary intervention (PCI).Atherosclerotic heart disease of native coronary artery with unstable angina pectorisI25.110
- Registration Number
- IRCT20151227025726N10
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
Patients referring to Shahid Modarres hospital cath lab
Patients more than 18 years old
Patients who are candidated for elective PCI surgery
Exclusion Criteria
Serum creatinine level more than 2 mg/dL
Active metabolic bone disease
Vitamin D supplementation receivement
Consuming anti-inflammatory drugs (except aspirin and statin)
Severe hepatic disease (Child-paugh C)
Ejection fraction less than 30%
Contraindications or hypersensitivity to calcitriol
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in CK-MB serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of CK-MB.;Change in Interleukin-6 serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of interleukin 6.;Change in total high sensitivity CRP serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of high sensitivity CRP.;Change in cardiac Troponin I serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of cardiac Troponin I.
- Secondary Outcome Measures
Name Time Method Myocardial infarction (MI). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;The need for Percutaneous Coronary Intervention (PCI). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;The need for Coronary Artery Bypass Graft (CABG). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;All-cause death. Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and telephone interview.