The effect of Mg on the cardiac biomarker proBNP
Phase 2
Completed
- Conditions
- Atherosclerotic heart disease.Atherosclerotic heart disease
- Registration Number
- IRCT201205069650N1
- Lead Sponsor
- Anesthesiology Research Center, Shahid Beheshtil Universityof medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
significant coronary artery stenosis (2VD or 3VD) and EF<45%. Exclusion criteria: 1.Conduction abnormality (branch block); 2.AF rhythm; 3.Diabetes mellitus. 4.cr>1.8; 5.Emergent surgery; 6.Unstable angina; 7.Redo surgery; 8.Combination surgery (carotid endarterectomy, vulvoplasty); 9.long QT syndrome, neuromuscular junction disorders.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ProBNP. Timepoint: before intervention, 24 hours after intervention. Method of measurement: ELISA based lab kit.
- Secondary Outcome Measures
Name Time Method Mechanical ventilation time. Timepoint: days on mechanical ventilation. Method of measurement: questionnaire.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie magnesium sulfate's effect on proBNP in coronary artery bypass grafting patients?
How does magnesium sulfate infusion compare to standard-of-care treatments in reducing proBNP levels post-coronary artery bypass grafting?
Which biomarkers correlate with magnesium sulfate efficacy in atherosclerotic heart disease patients undergoing CABG?
What adverse events are associated with magnesium sulfate infusion in cardiac surgery and how are they managed?
Are there combination therapies involving magnesium sulfate that enhance proBNP modulation in coronary artery bypass procedures?