Observational and diagnostical study on transient allostastic responses of thyroid function after cardiopulmonary resuscitation.

• Conditions: OPS 8-771OPS 8-772OPS 8-779; I46.0; I46.1; I46.9; I49.0; U69.13; Cardiac arrest with successful resuscitation; Sudden cardiac death, so described; Cardiac arrest, unspecified; Ventricular fibrillation and flutter

• Registration Number: DRKS00021695
• Lead Sponsor: Abteilung für Endokrinologie und Diabetologie Medizinische Klinik I Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH UK RUB

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Protocol A: Admission after cardiopulmonary resuscitation, minimum age of 18 years.

Protocol B: Admission after cardiopulmonary resuscitation, minimum age of 18 years, results of TSH and peripheral thyroid hormone concentrations already available or possibility to reorder these investigation in a post-hoc manner if consent has been obtained (i. e. time interval after venipuncture within the storage period of the central laboratory), inclusion after own consent of thepatient after reawakening, via custodian or independent consultant.

Exclusion Criteria

Protocol A:Missing data on thyroid homeostasis in the first blood specimen (obtained before 3 hours after admission), traumatic brain injury, persistent hints for thyroid dysfunction (not explained by NTIS/ESS/TACITUS) in consecutive investigations over several days after resuscitation, functionally relevant thyroid or pituitary disorder, as documented in ICD codes.

Protocol B: Exposure to radiocontrast agents less than 3 months ago, therapy with amiodarone (currently or during the previous 3 years), traumatic brain injury, pregnancy, known thyroid disease, consent not obtained within the routine storage period of the central laboratory, post-hoc-exclusion if evidence for true dysfunction the pituitary or the thyroid became available during the study period.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in TSH concentration after CPR compared to the value after 24 hours.

Secondary Outcome Measures

Name	Time	Method
Mortality dependent on pituitary thyrotropic partial function.