Antibodies Causing Epilepsy Syndromes
Completed
- Conditions
- auto immune encephalitisinflamed brain1000381610007951
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 1380
Inclusion Criteria
- Age of 18 and older.
- Status epilepticus or new onset seizures with signs of limbic encephalitis (clinical picture, MRI (FLAIR abnormalities), EEG abnormalities or CSF findings (CSF pleocytosis, increased IgG index, oligoclonal bands)
- Patients with acquired chronic focal epilepsy with an unknown cause.
- A subgroup of these patients, with chronic focal epilepsy, undergoing epilepsy surgery (without a known underlying cause of their epilepsy or possible (post) encephalitis changes, like mesiotemporal sclerosis and hippocampal sclerosis). These are patients with a pharmacoresistent epilepsy, not responding to first and second-line anti-epileptic drugs.
Exclusion Criteria
Patients < 18 years.
Epilepsy with known cause.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. characterise new antibody mediated clinical syndromes causing epilepsy.<br /><br>2. Measure the frequency of every individual antibody mediated syndrome causing<br /><br>epilepsy in adults.<br /><br>3. Look at outcome of individual antibody mediated syndrome causing epilepsy in<br /><br>adults. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- What clinical and epidemiological markers are linked to the specific,<br /><br>individual antibodies?<br /><br>- What markers define poor or good prognosis in adults?</p><br>