Elite Sport and Development of Asthma
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Eucapnic voluntary hyperventilation (EVH)
研究概览
简要总结
International studies have shown that elite athletes have a high prevalence of respiratory symptoms and asthma as compared to normal subjects. It is unclear whether the increased prevalence of asthma in elite athletes reflects "traditional asthma" or whether it is a special form of "sports asthma". The treatment of elite athletes with asthma seems to vary widely, and only a few studies have focused on the treatment of elite athletes with asthma. Further knowledge of the pathogenesis of sports asthma would lead to a greater understanding and better treatment of the condition. This study will investigate the type of airway inflammation in elite athletes and examine the effect of treatment with inhaled steroids in combination with long-acting beta-agonists versus placebo in the same group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Elite athletes
- •Informed consent
- •Doctor diagnosed asthma
排除标准
- •Current smoker or more than 10 pack-years
- •Pregnancy, breast feeding or planning pregnancy during the study.
- •ICS within the last 4 weeks prior to visit 1.
研究组 & 干预措施
Placebo
Placebo inhaler (sugar powder)
干预措施: Placebo (Drug)
Seretide
Seretide inhaler
干预措施: Seretide (Drug)
结局指标
主要结局
Eucapnic voluntary hyperventilation (EVH)
时间窗: End of study
Exhaled Nitric Oxide
时间窗: End of study
次要结局
- Respiratory symptoms(End of study)
- Lung function(End of study)
