NCT00686452Unknown不适用
Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Asthma and airway hyperreactivity prevalence in swimmers
研究概览
简要总结
Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are
- to compare the prevalence of asthma in swimmers and control subjects
- to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
- to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 14 Years 至 35 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •14 to 35 years old
- •To swim at least 10h per week
- •For control subjects, non-competitive healthy subjects
排除标准
- •any disease that may interfere with the tests for the controls
- •Triathletes are excluded
- •Obese or with a BMI more than 29
- •Former athletes (control group)
结局指标
主要结局
Asthma and airway hyperreactivity prevalence in swimmers
时间窗: 3 measurements in the year
次要结局
- Airway inflammation and remodeling in swimmers(3 measurements in the year and a bronchial biopsy)
研究者
研究点 (1)
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