Waveform Analysis for Vascular Evaluation and Cardiovascular Advancements in Research and Enhancement
Recruiting
- Conditions
- valvular heart diseases and aneurysms (or dilation of a blood vessel)100469731000759310002363
- Registration Number
- NL-OMON56849
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 800
Inclusion Criteria
- >18 years of age - informed consent - diagnosed with valvular heart disease
or thoracic aortic aneurysm for surgerical procedure - scheduled for coronary
artery bypass grafting with good left ventrical function
Exclusion Criteria
Subjects of which the non-invasive blood pressure cannot be measured with the
finger cuff according to the Instruction for Use of the CS/EV1000 system
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary endpoint of the study is to assess whether the non-invasive<br /><br>arterial pressure waveform measured at the finger level exhibits any<br /><br>distinctive morphological characteristics. In particular, analysis will be<br /><br>focused on the following characteristics:<br /><br><br /><br>· Prolongation of the total duration of ejection: systolic phase of the<br /><br>reconstructed aortic pressure waveform<br /><br><br /><br>· Prolongation of the systolic upstroke time<br /><br><br /><br>· The slope of the pressure rise during systole: dP/dt<br /><br><br /><br>· The presence and position of the anacrotic and dicrotic notches<br /><br><br /><br>· Alterations of the shape of the pulse contour<br /><br><br /><br>· Increase of time-constant of the diastolic phase of the waveform<br /><br><br /><br>· The presence of the high-frequency components in the reconstructed aortic<br /><br>pressure waveform<br /><br><br /><br>· Reduction in pulse pressure</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Differences in accuracy of the model between males and females<br /><br><br /><br>- Differences in the accuracy of the model related to the cause of thoracic<br /><br>aortic aneurysm such as genetic or age related </p><br>