Can alpha- defensin and other synovial fluid biomarkers detect joint infections earlier in children? - nil

Karthick Rangasamy0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年8月21日

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•Inclusion criteria for Disease cases:
•1) Children up to 17 years of age presented with suspected septic joint (High-grade fever, joint
•line tenderness, limited restriction of joint movements with joint effusion, difficulty in
•ambulation).
•2) All medium and large joints like hip, knee, ankle, shoulder, elbow, and wrist will be included.
•(If there are multiple joint involvements, the joint which is more symptomatic and has more
•effusion will be used for sample collection)
•Inclusion criteria for Disease controls:
•1) Children up to 16 years of age presented with multiple joint pain and effusion. (Morning
•stiffness, associated small joint involvement in hand and foot, associated with other system
•involvement like skin rash, generalized lymph adenopathy or Hepatosplenomegaly)
•Inclusion criteria for Healthy controls:
•Children up to 17 years of age undergo a procedure that is not related to infection or
•intraarticular pathologies. The children who sustained trauma will be of control, but joint
•aspiration will be done from the contralateral normal joint.

•Exclusion criteria for cases:
•1) Parents of the children not willing to give consent/participate.
•2) Age >= 18 years.
•3) Children sustained any major trauma around the joint in the past 2 months (other joint sites of
•the same children may be included) or any tumour around the joint.
•Exclusion criteria for both disease and healthy controls:
•1) History of recent infection in the past 4 months.
•2) Exposed to antibiotics in the past 10 days.

发起方

Karthick Rangasamy