Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Glucose infusion rate
研究概览
简要总结
This study evaluates the role of endothelin in insulin stimulated vasodilation and glucose uptake. The subjects will complete an hyperinsulinemic euglycemic clamp with and without blockade of the endothelin receptors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Type 2 diabetes OR healthy control (no type 2 diabetes)
排除标准
- •heart disease
- •pregnancy or birth within 3 month
- •Kidney disease
- •beta-blockers
- •insulin treatment (for type 2 diabetics)
研究组 & 干预措施
Healthy controls
BQ123 (25 nmol/min), BQ788 (25 nmol/min)
干预措施: Insulin clamp (Drug)
Type 2 diabetics
BQ123 (25 nmol/min), BQ788 (25 nmol/min)
干预措施: BQ123 + BQ788 (Drug)
Type 2 diabetics
BQ123 (25 nmol/min), BQ788 (25 nmol/min)
干预措施: Insulin clamp (Drug)
Type 2 diabetics
BQ123 (25 nmol/min), BQ788 (25 nmol/min)
干预措施: BQ123 (Drug)
Healthy controls
BQ123 (25 nmol/min), BQ788 (25 nmol/min)
干预措施: BQ123 (Drug)
Healthy controls
BQ123 (25 nmol/min), BQ788 (25 nmol/min)
干预措施: BQ123 + BQ788 (Drug)
结局指标
主要结局
Glucose infusion rate
时间窗: 3.5 hours
Glucose infusion rate required to maintain euglycemia during insulin clamp with and without endothelin blockade
Leg blood flow
时间窗: 3.5 hours
Effect of endothelin receptor blockade on leg blood flow (ultrasound Doppler) during insulin clamp with and without endothelin blockade
次要结局
未报告次要终点
研究者
Stefan Mortensen
Professor
University of Southern Denmark