NCT00742066Unknown不适用
Insulin-induced Microvascular Activity in Patients With Essential Hypertension: a Possible Role for Angiotensin II AT1-receptor Blockers.
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- functional recruitment of capillaries in the skin
研究概览
简要总结
In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular effects in normotensive control subjects?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •hypertensive subjects:
- •18-60 years
- •untreated hypertension >140/90mmHg.
- •normotensive subjects:
- •18-60 years
- •Blood pressure <140/90 mmHg.
排除标准
- •Obesity (BMI>27kg/m2)
- •Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
- •Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
- •Alcohol use >4U/day
- •Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
- •Wearing contact lenses
研究组 & 干预措施
I
Experimental
Irbesartan
干预措施: Irbesartan (Drug)
II
Active Comparator
Felodipine
干预措施: Felodipine (Drug)
III
Placebo Comparator
Placebo
干预措施: Placebo (Drug)
结局指标
主要结局
functional recruitment of capillaries in the skin
时间窗: July 2009
次要结局
- perfused capillary density in the nailfold(July 2009)
- Endothelium- (in)dependent vasodilatation of finger skin microcirculation(July 2009)
- Density of arterioles, capillaries and venules in the bulbar conjunctiva.(July 2009)
- Diameter of arterioles and venules in the bulbar conjunctiva(July 2009)
研究者
研究点 (1)
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