Unknown Manufacturer • Irbesartan is indicated to treat hypertension and diabetic nephropathy in hypertensive patients with type 2 diabetes, elevated serum creatinine, and proteinuria. A combination product with hydrochlorothiazide is indicated for hypertension in patients with uncontrolled hypertension with monotherapy or first line in patients not expected to be well controlled with monotherapy.
Irbesartan is an angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure.
Irbesartan prevents angiotensin II binding to the AT receptor in tissues like vascular smooth muscle and the adrenal gland. Irbesartan and its active metabolite bind the AT receptor with 8500 times more affinity than they bind to the AT receptor. Irbesartan's prevention of angiotensin II binding causes vascular smooth muscle relaxation and prevents the secretion of aldosterone, lowering blood pressure. Angiotensin II would otherwise bind to the AT receptor, inducing vasoconstriction and aldosterone secretion, raising blood pressure.
