Role of Angiotensin II in Insulin-induced Microvascular Activity
Not Applicable
Completed
- Conditions
- Insulin SensitivityMicrocirculation
- Interventions
- Registration Number
- NCT01024543
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake. Objectives: Does infusion of Angiotensin II increase insulin-mediated glucose uptake via enhanced insulin-mediated microvascular function in healthy subjects?
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
1.18-60 years 2.Caucasian 3.Blood pressure <140/90 mmHg.
Exclusion Criteria
- Obesity (BMI>27kg/m2)
- Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
- Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
- Smoking
- Alcohol use >4U/day
- Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
- Pregnancy
- Wearing contact lenses
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo Placebo Placebo Angiotensin II Angiotensin II Angiotensin II Phenylephrine Phenylephrine Phenylephrine
- Primary Outcome Measures
Name Time Method functional recruitment of capillaries in the skin January 2009
- Secondary Outcome Measures
Name Time Method perfused capillary density in the nailfold January 2009 Endothelium- (in)dependent vasodilatation of finger skin microcirculation January 2006 Insulin sensitivity January 2009
Trial Locations
- Locations (1)
Maastricht University Medical Centre
🇳🇱Maastricht, P.o. Box 5800, Netherlands, Netherlands