NCT01024543已完成不适用
Role of Angiotensin II in Insulin-induced Microvascular Activity
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- functional recruitment of capillaries in the skin
研究概览
简要总结
In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake. Objectives: Does infusion of Angiotensin II increase insulin-mediated glucose uptake via enhanced insulin-mediated microvascular function in healthy subjects?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •1.18-60 years 2.Caucasian 3.Blood pressure <140/90 mmHg.
排除标准
- •Obesity (BMI>27kg/m2)
- •Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
- •Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
- •Alcohol use >4U/day
- •Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
- •Wearing contact lenses
研究组 & 干预措施
Placebo
Sham Comparator
Placebo
干预措施: Placebo (Drug)
Angiotensin II
Experimental
Angiotensin II
干预措施: Angiotensin II (Drug)
Phenylephrine
Active Comparator
Phenylephrine
干预措施: Phenylephrine (Drug)
结局指标
主要结局
functional recruitment of capillaries in the skin
时间窗: January 2009
次要结局
- perfused capillary density in the nailfold(January 2009)
- Endothelium- (in)dependent vasodilatation of finger skin microcirculation(January 2006)
- Insulin sensitivity(January 2009)
研究者
研究点 (1)
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