Insulin-induced Microvascular Dilatation During a Physiological Stimulus - Studies in Hypertension and Obesity.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Functional recruitment of capillaries in the skin.
研究概览
简要总结
In this study we will examine if the insulin-induced microvascular effects will occur after a physiological stimulus (i.e. a oral glucose tolerance test). With that the physiological importance of the insulin-induced microvascular dilatation can be elucidated. In this study we hypothesize that oral glucose intake and consequently the endogenous induced hyperinsulinemia will lead to insulin-induced microvascular dilatation in healthy normotensive subjects. Furthermore, we suggest that the insulin-mediated microvascular dilatation, resulting from this physiological induced hyperinsulinemia, will be less in hypertensive and obese subjects compared to healthy controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy normotensive subjects:
- •18-60 years
- •Blood pressure <140/90 mmHg
- •obese normotensive subjects:
- •18-60 years
- •Blood pressure <140/90 mmHg
- •BMI 30-38kg/m2
- •hypertensive subjects:
- •18-60 years
- •Untreated hypertension >140/90mmHg.
- •Exclusion Criteria for healthy normotensive and hypertensive subjects:
- •Obesity (BMI>27kg/m2)
- •Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
- •Diabetes mellitus according to the criteria of the ADA
- •Alcohol use >4U/day
- •Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
- •Wearing contact lenses
- •for normotensive obese subjects:
- •Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
- •Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
- •Alcohol use >4U/day
- •Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
- •Wearing contact lenses
排除标准
- 未提供
结局指标
主要结局
Functional recruitment of capillaries in the skin.
时间窗: January 2009 - January 2010
次要结局
- Perfused capillary density in the nailfold.(January 2009 - January 2010)
- Endothelium- (in)dependent vasodilatation of finger skin microcirculation(January 2009 - January 2010)
- Density of arterioles, capillaries and venules in the bulbar conjunctiva.(January 2009 - January 2010)
- Diameter of arterioles and venules in the bulbar conjunctiva.(January 2009 - January 2010)
- Insulin sensitivity (HOMA-IR)(January 2009 - January 2010)