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Microvascular Dilatation After Endogenous Induced Hyperinsulinemia

Not Applicable
Completed
Conditions
Hypertension
Obesity
Registration Number
NCT00742456
Lead Sponsor
Maastricht University Medical Center
Brief Summary

In this study we will examine if the insulin-induced microvascular effects will occur after a physiological stimulus (i.e. a oral glucose tolerance test). With that the physiological importance of the insulin-induced microvascular dilatation can be elucidated. In this study we hypothesize that oral glucose intake and consequently the endogenous induced hyperinsulinemia will lead to insulin-induced microvascular dilatation in healthy normotensive subjects. Furthermore, we suggest that the insulin-mediated microvascular dilatation, resulting from this physiological induced hyperinsulinemia, will be less in hypertensive and obese subjects compared to healthy controls.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
48
Inclusion Criteria

healthy normotensive subjects:

  1. 18-60 years
  2. Caucasian
  3. Blood pressure <140/90 mmHg

obese normotensive subjects:

  1. 18-60 years
  2. Caucasian
  3. Blood pressure <140/90 mmHg
  4. BMI 30-38kg/m2

hypertensive subjects:

  1. 18-60 years
  2. Caucasian
  3. Untreated hypertension >140/90mmHg.

Exclusion Criteria for healthy normotensive and hypertensive subjects:

  1. Obesity (BMI>27kg/m2)
  2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
  3. Diabetes mellitus according to the criteria of the ADA
  4. Smoking
  5. Alcohol use >4U/day
  6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
  7. Pregnancy
  8. Wearing contact lenses

for normotensive obese subjects:

  1. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
  2. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
  3. Smoking
  4. Alcohol use >4U/day
  5. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
  6. Pregnancy
  7. Wearing contact lenses
Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Primary Outcome Measures
NameTimeMethod
Functional recruitment of capillaries in the skin.January 2009 - January 2010
Secondary Outcome Measures
NameTimeMethod
Perfused capillary density in the nailfold.January 2009 - January 2010
Endothelium- (in)dependent vasodilatation of finger skin microcirculationJanuary 2009 - January 2010
Density of arterioles, capillaries and venules in the bulbar conjunctiva.January 2009 - January 2010
Diameter of arterioles and venules in the bulbar conjunctiva.January 2009 - January 2010
Insulin sensitivity (HOMA-IR)January 2009 - January 2010

Trial Locations

Locations (1)

University Hospital Maastricht

🇳🇱

Maastricht, Netherlands

University Hospital Maastricht
🇳🇱Maastricht, Netherlands

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