The study of effectiveness of platelet-rich plasma (PRP) treatment for lichen planus pigmentosus (pilot study)

Phase 3

• Conditions: ichen planus pigmentosus; Lichen planus pigmentosus; Platelet-rich plasma; Pigmentation; Melanin

• Registration Number: TCTR20230202004
• Lead Sponsor: Institute of dermatology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-02
• Study Completion: 2023-05-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: nknown
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1. Patients who were diagnosed with lichen planus pigmentosus, age 18 - 60 years
2. Has facial LPP lesion for at least 6 months
3. Histology confirmed LPP as evidenced by perivascular infiltrate, lichenoid reaction, melanophages and pigment pigmentation (melanin) accumulates under the epidermis and dermis.
4. Patch test result is negative

Exclusion Criteria

1. Patients who are pregnant or breastfeeding
2. Patients with a history of keloids, hypertrophic scars, herpes virus infection or skin disease around the lesion
3. Patients with blood disorders, liver disease or patients receiving chemotherapy/ anticoagulants
4. Patients with hyperpigmentation from other conditions, such as pigmented contact dermatitis, with positive patch test results, fixed drug eruption, lichenoid drug reaction, ochronosis, melasma, PIH, endocrinopathies, etc.
5. Patients with a history of treatment using topical bleaching agents and lasers within 6 months prior to study participation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quartile grading scale (QGS) 0,2,4,6,8,12 weeks quartile grading scale (QGS)

Secondary Outcome Measures

Name	Time	Method
Patient satisfaction 0,2,4,6,8,12 weeks Patient satisfaction score