The Influence of Lung Protective Ventilation During Pulmonary Lobectomy on Clinical Outcome in Pediatric Patients

Seoul National University Hospital1 site in 1 country114 target enrollmentFebruary 2016

ConditionsPulmonary Complication

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Pulmonary Complication
Sponsor: Seoul National University Hospital
Enrollment: 114
Locations: 1
Primary Endpoint: The number of patients with pulmonary complication
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in pediatric patients. The hypothesis is that application of low tidal volume, intermittent alveolar recruitment and adequate positive end-expiratory pressure (PEEP) would be more beneficial than conventional ventilation in children.

Registry

clinicaltrials.gov

Start Date

February 2016

End Date

February 2018

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Seoul National University Hospital

Responsible Party

Principal Investigator

Jin-Tae Kim

Associate professor

Seoul National University Hospital

Eligibility Criteria

Inclusion Criteria

•Children who are scheduled for lung lobectomy under general anesthesia
•ASA physical status I, II

Exclusion Criteria

•History of airway or pulmonary interstitial disease
•Active URI
•Systemic inflammatory response disease
•cardiac disease

Outcomes

Primary Outcomes

The number of patients with pulmonary complication

Time Frame: up to postoperative 7 days

The number of patients with pulmonary complication including atelectasis, pulmonary infiltration, pulmonary edema, pulmonary infection, pleural effusion and pulmonary embolism

Secondary Outcomes

The number of patients with extrapulmonary complication(through study completion, an average of 1 year)
Mean duration of mechanical ventilation(through study completion, an average of 1 year)
The number of patients with desaturation(During surgery)
Mean duration of ICU stay(through study completion, an average of 1 year)