Comparison of POCD between Propofol induction and Ketofol induction

Completed

Conditions: Medical and Surgical,

Registration Number: CTRI/2019/05/019456

Lead Sponsor: Deen dayal upadhyay hospital New Delhi

Brief Summary: Ketamine and Propofol admixture is associated with improved hemodynamics when used as an induction agent. Postoperative cognitive dysfunction is a common adverse event after general anesthesia which represents a decline in a variey of neuropsychological domains including memory, executive functioning and speed of thought processing. Since, Ketamine has dissociativeproperties and Ketofol is being increasingly used for its hemodynamic stability profile, we decide to compare the incidence of POCD with Ketamine(0.75mg/kg) and Propofol(1.25mg/kg) combination when compared to Propofol(2mg/kg) alone for induction of general anesthesia.

A battery of neuropsychological tests will be used to assess POCD which can be debilitating in day care surgeries.

Neuropsychological tests are Mini mental state examination, California verbal learning test, Digit span test, Stroop card word and colour test.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 100

Inclusion Criteria

ASA 1 AND 2 SURGERY NOT EXPECTED TO CROSS 2 HOURS EDUCATION ATLEAST 10TH STANDARD PASS.

Exclusion Criteria

PATIENT REFUSAL HISTORY OF KNOWN ALLERGY TO DRUGS BEING USED HISTORY OF PSYCHIATRIC ILLNESS DRUG OR ALCOHOL ABUSE AND CHRONIC PAIN HISTORY OF TREATMENT WITH ANTIANXIETY OOPIIOD ANTICONVULSANTS AND ANTIPYSCHOTIC DRUGS PREGNANT AND LACTATING WOMEN PATIENT WITH HISTORY OF ALZHEIMERS DISEASE AND MMSE SCORE LESS THEN 23.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TO OBSERVE THE INCIDENCE OF POST OPERATIVE COGNITIVEDYSFUNCTION AS PER POSITIVE NEUROPSYCHOLOGICAL TESTS IN BOTH THE GROUPS	POST OPERATIVE 5 MINS, 30 MINS , 1 HOUR, 2 HOUR AND 4 HOUR

Secondary Outcome Measures

Name	Time	Method
To correlate Richmond agitation sedation scale wth incidence of positive neuropsychological tests for POCD.	To assess the relation of age and education on POCD in ketofol and propofol group.

Trial Locations

Locations (1): DEEN DAYAL UPADHYAY HOSPITAL
🇮🇳
West, DELHI, India
DEEN DAYAL UPADHYAY HOSPITAL
🇮🇳West, DELHI, India
Dr Bharath B K
Principal investigator
9844003798
bkbharath3021@gmail.com