Comparison of effect of propofol versus sevoflurane on renal function in patients undergoing spine surgery
试验速览
- 阶段
- 2/3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- Urine output
研究概览
简要总结
Acute kidney injury affects 6-8% of patients undergoing surgery and is associated with increased mortality and increased risk of chronic kidney disease, Alongside indirect measurements of glomerular filtration rate and decreased urine output are the main diagnostic criteria for acute kidney injury. Intraoperative oliguria is a risk factor for subsequent acute kidney injury. This study is aimed to compare propofol vs sevoflurane anesthesia on renal excretory function, urinary markers for kidney injury before anesthesia induction, during anesthesia before surgery commences and in the post operative period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA 1 and 2 Elective spine surgery.
排除标准
- •Allergic to Propofol and Sevoflurane Insulin treated Diabetes mellitus BMI more than 37/kg/meter square Kidney disease according to KDIGO criteria NYHA class 3 and 4.
结局指标
主要结局
Urine output
时间窗: 30 minutes into anesthesia | 0-2 hours in the post operative period | 24 hours after anesthesia
次要结局
- Kidney injury molecule(Serum creatinine)
研究者
Dr Roshni Raman
Sri ramachandra institute of higher education and research